Universität Zürich - Tissue Biology Research Unit (UZH-TBRU)

Universität Zürich
Tissue Biology Research Unit
August Forel Strasse 7
8008 Zürich


Lead Investigator and Coordinator


Prof. Dr. Ernst Reichmann
Coordinator and Leader of Workpackage 04
Phone: +41 44 634 89 11
Fax: +41 44 634 89 18


Project Staff


Dr. Daniela Marino
Project Manager
Phone: +41 44 634 89 32
Fax: +41 44 634 89 18


Fabienne Hartmann
Head of the GMP production
Phone: +41 44 634 89 20
Fax: +41 44 634 89 18

Institute Presentation

The Tissue Biology Research Unit (TBRU) is the basic science oriented experimental research laboratory of the Department of Surgery of the University Children's Hospital Zurich, Switzerland. It was established in 2001 by Prof. Martin Meuli, Prof. Urs Stauffer and Prof. Dr. Ernst Reichmann based on the philosophy that many unsolved clinical problems are best addressed if clinicians and basic scientists unite and agree upon a common mission. The explicit intent of this joint venture-type research is to develop together innovative regenerative medicine approaches in the laboratory to be then applied clinically. The TBRU consists of a fully equipped research laboratory where scientists perform basic and applied science. Human biological material is provided by the University Children’s Hospital in Zurich. 

The main goal of our research is the in vivo construction of an autologous skin substitute that ideally approximates the qualities of human skin and that can be used in procedures of skin replacement in reconstructive and plastic surgery. In the last years, the TBRU has developed two novel cellular skin grafts: denovoDerm (an autologous dermal substitute, to be used in combination with split-thickness skin) and denovoSkin (an autologous dermo-epidermal skin substitute). Extensive pre-clinical results on both small (rats) and large (pigs) animal models have shown the great regeneration potential of both grafts in full-thickness skin defects.  Thanks to EuroSkinGraft the clinical outcome of denovoDerm and denovoSkin will now be exploited.

In view of the collaborative project, Prof. Dr. Ernst Reichmann will perform scientific and project coordination. Dr. Daniela Marino will be involved in project management, reporting, dissemination and training. Mrs Fabienne Hartmann will be coordinating the GMP-production of the skin grafts; a newly hired technician will support her work.