Publications

Human Eccrine Sweat Gland Cells Turn into Melanin-Uptaking Keratinocytes in Dermo-Epidermal Skin Substitutes  Böttcher-Haberzeth S, Biedermann T, Pontiggia L, Braziulis E, Schiestl C, Hendriks B, Eichhoff OM, Widmer DS, Meuli-Simmen C, Meuli M, Reichmann E. J Invest Dermatol. 2012 Sep 13. doi: 10.1038/jid.2012.290. [Epub ahead of print]

Human amniotic fluid derived cells can competently substitute dermal fibroblasts in a tissue-engineered dermo-epidermal skin analog. Hartmann-Fritsch F, Hosper N, Luginbühl J, Biedermann T, Reichmann E, Meuli M. Pediatr Surg Int. 2012 Nov 9. [Epub ahead of print]

Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation? Biedermann T, Böttcher-Haberzeth S, Klar AS, Pontiggia L, Schiestl C, Meuli-Simmen C, Reichmann E, Meuli M. Pediatr Surg Int. 2012 Nov 13. [Epub ahead of print]

Trooping the color: restoring the original donor skin color by addition of melanocytes to bioengineered skin analogs. Böttcher-Haberzeth S, Klar AS, Biedermann T, Schiestl C, Meuli-Simmen C, Reichmann E, Meuli M. Pediatr Surg Int. 2012 Nov 30. [Epub ahead of print]

 Optimizing in vitro culture conditions leads to a significantly shorter production time of human dermo-epidermal skin substitutes. Pontiggia L, Klar A, Böttcher-Haberzeth S, Biedermann T, Meuli M, Reichmann E.SourceTissue Biology Research Unit, University Children's Hospital Zurich, Zurich, Switzerland. Pediatr Surg Int. 2013 Feb 3. [Epub ahead of print]

A new model for preclinical testing of dermal substitutes for human skin reconstruction Hartmann-Fritsch F, Biedermann T, Braziulis E, Meuli M, Reichmann E.Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland. Pediatr Surg Int. 2013 Feb 1. [Epub ahead of print]

Tissue Engineering of Skin for Wound Coverage. Biedermann T, Böttcher-Haberzeth S, Reichmann E. Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland. Eur J Pediatr Surg. 2013 Aug 27. [Epub ahead of print]

Outcome of Burns Treated With Autologous Cultured Proliferating Epidermal Cells: A Prospective Randomized Multicenter Intrapatient Comparative Trial. Gardien KL, Marck RE, Bloemen MC, Waaijman T, Gibbs S, Ulrich MM, Middelkoop E; Dutch Outback Study Group1..Cell Transplant. 2016;25(3):437-48.

Cell therapy for full-thickness wounds: are fetal dermal cells a potential source? Akershoek JJ, Vlig M, Talhout W, Boekema BK, Richters CD, Beelen RH, Brouwer KM, Middelkoop E, Ulrich MM. Cell Tissue Res. 2016 Apr;364(1):83-94.

Transepidermal water loss measured with the Tewameter TM300 in burn scars. Gardien KL, Baas DC, de Vet HC, Middelkoop E. Burns. 2016 Nov;42(7):1455-1462. doi: 10.1016/j.burns.2016.04.018.

Digital image analysis versus clinical assessment of wound epithelialization: a validation study Bloemen MC1, Boekema BK, Vlig M, van Zuijlen PP, Middelkoop E. Epub 2012 Feb 29

De Novo Epidermal Regeneration Using Human Eccrine Sweat Gland Cells: Higher Competence of Secretory over Absorptive Cells Luca Pontiggia, Thomas Biedermann, Sophie Böttcher-Haberzeth, Carol Oliveira, Erik Braziulis, Agnieszka S. Klar, Claudia Meuli-Simmen, Martin Meuli, Ernst Reichmann J Invest Dermatol. 2014 Jun;134(6):1735-42.

Bioengineering Dermo-Epidermal Skin Grafts with Blood and Lymphatic Capillaries Daniela Marino, Joachim Luginbühl, Simonetta Scola, Martin Meuli and Ernst Reichmann Science Translational Medicine  29 Jan 2014: Vol. 6, Issue 221, pp. 221ra14

Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells Agnieszka S. Klara, Sinan Güvenb, Thomas Biedermanna, Joachim Luginbühla, Sophie Böttcher-Haberzetha, Claudia Meuli-Simmend, Martin Meulic, Ivan Martinb, Arnaud Scherberichb, Ernst Reichmann Biomaterials. 2014 Jun;35(19):5065-78.

Analysis of blood and lymph vascularization patterns in tissue-engineered human dermo-epidermal skin analogs of different pigmentation Klar, A.S., Böttcher-Haberzeth, S., Biedermann, T. et al. Pediatr Surg Int (2014) 30: 223. Pediatr Surg Int. 2014 Feb;30(2):223-31.

Tissue engineering of skin: human tonsil-derived mesenchymal cells can function as dermal fibroblasts Böttcher-Haberzeth, S., Biedermann, T., Klar, A.S. et al. Pediatr Surg Int (2014) 30: 213.

Tissue-engineered dermo-epidermal skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation Biedermann, T., Klar, A.S., Böttcher-Haberzeth, S. et al. Pediatr Surg Int (2014) 30: 165.

Progress towards cell-based burn wound treatments Kim LM Gardien, Esther Middelkoop & Magda MW Ulrich March 2014 ,Vol. 9, No. 2, Pages 201-218

Visualisation of newly synthesised collagen in vitro and in vivo Corien Oostendorp , Peter J.E. Uijtdewilligen, Elly M. Versteeg , Theo G. Hafmans, Ellen H. van den Bogaard, Paul K.J.D. de Jonge , Ali Pirayesh, Johannes W. Von den Hoff, Ernst Reichmann, Willeke F. Daamen, Toin H. van Kuppevelt Sci Rep. 2016 Jan 7;6:18780

Differential expression of granulocyte, macrophage, and hypoxia markers during early and late wound healing stages following transplantation of tissue-engineered skin substitutes of human origin Klar, A.S., Böttcher-Haberzeth, S., Biedermann, T. et al. Pediatr Surg Int (2014) 30: 1257.

Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes Biedermann, T., Klar, A.S., Böttcher-Haberzeth, S. et al. Pediatr Surg Int (2015) 31: 69.

The Influence of Stromal Cells on the Pigmentation of Tissue-Engineered Dermo-Epidermal Skin Grafts Biedermann Thomas, Böttcher-Haberzeth Sophie, Klar Agnieszka S., Widmer Daniel S., Pontiggia Luca, Weber Andreas D., Weber Daniel M., Schiestl Clemens, Meuli Martin, and Reichmann Ernst. Tissue Engineering Part A. March 2015, 21(5-6): 960-969.

Characterization of pigmented dermo-epidermal skin substitutes in a long-term in vivo assay Böttcher-Haberzeth, S., Biedermann, T., Klar, A. S., Widmer, D. S., Neuhaus, K., Schiestl, C., Meuli, M. and Reichmann, E. (2015), Characterization of pigmented dermo-epidermal skin substitutes in a long-term in vivo assay. Exp Dermatol, 24: 16–21.

Collagen hydrogels strengthened by biodegradable meshes are a basis for dermo-epidermal skin grafts intended to reconstitute human skin in a one-step surgical intervention Hartmann-Fritsch, F., Biedermann, T., Braziulis, E., Luginbühl, J., Pontiggia, L., Böttcher-Haberzeth, S., van Kuppevelt, T. H., Faraj, K. A., Schiestl, C., Meuli, M., and Reichmann, E. (2016) Collagen hydrogels strengthened by biodegradable meshes are a basis for dermo-epidermal skin grafts intended to reconstitute human skin in a one-step surgical intervention. J Tissue Eng Regen Med, 10: 81–91.

Characterization of vasculogenic potential of human adipose-derived endothelial cells in a three-dimensional vascularized skin substitute Klar, A.S., Güven, S., Zimoch, J. et al. Pediatr Surg Int (2016) 32: 17.

Visualisation of newly synthesised collagen in vitro and in vivo Oostendorp, C. et al. Visualisation of newly synthesised collagen in vitro and in vivo. Sci. Rep. 6, 18780

The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 279024.